STEROID
Stabilization of lysosomal membranes à
increased GAG
TIGR gene expression à
decrease the MMP
Expression of collagen, elastin, laminin, fibronectin à
increased TM resistance
Resistance to outflow increased due to
biological edema caused by ECM –PG + GAG
Outflow-enhancing PGs such as PGF2α
decreased
Inhibition of phagocytosis by
endothelial cells à
accumulation of debris in TM
Decreased proteinases including fibrinolytic enzymes, stromolysin,
MMPs
No comments:
Post a Comment