Differentiation of Retinal Cells

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The inner layer of the optic cup contains the pluripotent retinal progenitor cells, which differentiate in a specific chronologic sequence and defined histogenic order into the final seven retinal cell types. In general, the Ganglion cells differentiate first, followed by the cone photoreceptors, amacrine cells, horizontal cells, and finally, the rod photoreceptors, bipolar cells, and Müller cells.